Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830264 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL5826547 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL9685516 | 0.79 | KDM4E (0.77) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| Hydrochloric Acid SCHEMBL9684702 | 0.78 | KDM4E (0.75) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL2838064 | 0.75 | KDM4E (0.55) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL2833930 | 0.74 | MAOA (0.52) | ALDH1A1KDM4EKMT2APKM | |
| SCHEMBL8444755 | 0.74 | MAOA (0.43) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| Hydrochloric Acid SCHEMBL9686560 | 0.73 | MAOA (0.50) | ALDH1A1KDM4EKMT2APKM | |
| SCHEMBL2123230 | 0.72 | AURKA (0.37) | ALDH1A1KDM4EPDE10AADORA2AADORA1 | |
| SCHEMBL14843245 | 0.70 | AR (0.36) | ALDH1A1KDM4EKMT2AMEN1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307078-B1 | QUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1992-08-26 | — | — | EP | disclosed |
| US-5051508-A | Antisecretory agents and enzyme inhibitors as antiulcer agents | SMITHKLINE BECKMAN INTERCREDIT B.V. (NL) | 1991-09-24 | — | — | US | disclosed |
| EP-0307078-A1 | Quinoline derivatives, process for their preparation and pharmaceutical compositions containing them | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1989-03-15 | — | — | EP | disclosed |