Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | LMNA | P02545 | 6/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.70 |
| ▸ | HPGD | P15428 | 5/20 | 0.70 |
| ▸ | BRD4 | O60885 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | TOP2A | P11388 | 1/20 | 0.67 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.67 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685571 | 0.88 | ALDH1A1 (0.61) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9686875 | 0.88 | ALDH1A1 (0.73) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9685581 | 0.87 | ALDH1A1 (0.55) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL30605634 | 0.85 | ALDH1A1 (0.74) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL11392814 | 0.85 | ALDH1A1 (0.74) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9685705 | 0.85 | ALDH1A1 (0.58) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL11026221 | 0.84 | ALDH1A1 (0.73) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL10924498 | 0.83 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9686688 | 0.83 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9686810 | 0.83 | ALDH1A1 (0.50) | ALDH1A1KDM4ELMNAHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288519-A4 | 1-TERTIARY-ALKYL-SUBSTITUTED NAPHTHYRIDINE- AND QUINOLINE-CARBOXYLIC ACID ANTIBACTERIAL AGENTS | — | 1992-04-15 | — | — | EP | disclosed |
| US-4965273-A | Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents | BRISTOL-MYERS COMPANY (US) | 1990-10-23 | — | — | US | disclosed |
| US-4954507-A | 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents | BRISTOL-MYERS COMPANY (US) | 1990-09-04 | — | — | US | disclosed |
| EP-0288519-A1 | 1-TERTIARY-ALKYL-SUBSTITUTED NAPHTHYRIDINE- AND QUINOLINE-CARBOXYLIC ACID ANTIBACTERIAL AGENTS | Bristol-Myers Squibb Company (US) | 1988-11-02 | — | — | EP | disclosed |
| EP-0266576-A2 | 1-Tert-alkyl-substituted naphthyridine and quinoline carboxylic acids as antibacterial agents | Bristol-Myers Squibb Company (US) | 1988-05-11 | — | — | EP | disclosed |
| WO-1988002627-A1 | 1-TERTIARY-ALKYL-SUBSTITUTED NAPHTHYRIDINE- AND QUINOLINE-CARBOXYLIC ACID ANTIBACTERIAL AGENTS | BRISTOL-MYERS COMPANY (US) | 1988-04-21 | — | — | WO | disclosed |