Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685762 | 1.00 | KCNA5 (0.42) | KCNA5MAPK1ABCC9NPC1RAB9A | |
| SCHEMBL9029813 | 1.00 | KCNA5 (0.42) | KCNA5MAPK1ABCC9NPC1RAB9A | |
| SCHEMBL9030630 | 0.81 | ABCC9 (0.39) | ABCC9 | |
| SCHEMBL9029521 | 0.81 | ABCC9 (0.39) | ABCC9 | |
| SCHEMBL8443291 | 0.79 | ABCC9 (0.41) | ABCC9 | |
| SCHEMBL9265492 | 0.79 | KCNA5 (0.53) | KCNA5ABCC9NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9265505 | 0.79 | KCNA5 (0.53) | KCNA5ABCC9NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9265483 | 0.79 | KCNA5 (0.53) | KCNA5ABCC9NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9030169 | 0.78 | HTT (0.38) | ABCC9NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL9272458 | 0.77 | KCNA5 (0.47) | KCNA5ABCC9NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164509-A | BENZODIAZOLO ANALOGS | E. R. SQUIBB & SONS, INC. (US) | 1992-11-17 | — | — | US | claimed |
| EP-0488107-A2 | Tricyclic benzodiazole analogs and their use in the treatment of cardiovascular disorders | E.R. SQUIBB & SONS, INC. (US) | 1992-06-03 | — | — | EP | claimed |
| US-5164509-A | BENZODIAZOLO ANALOGS | E. R. SQUIBB & SONS, INC. (US) | 1992-11-17 | — | — | US | disclosed |