SCHEMBL9685763

SCHEMBL9685763

CN(C)Nc1cccc(CN2CCCC2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 1/20 0.53
ALDH1A1 P00352 4/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
TDP1 Q9NUW8 1/20 0.51
KDM4E B2RXH2 1/20 0.48
GAA P10253 1/20 0.48
CYP2D6 P10635 2/20 0.47
CYP2C9 P11712 1/20 0.47
HIF1A Q16665 1/20 0.47
DDB1 Q16531 1/20 0.46
CRBN Q96SW2 1/20 0.46
HTT P42858 1/20 0.45
HRH3 Q9Y5N1 4/20 0.44
CDK5 Q00535 1/20 0.44
CDK5R1 Q15078 1/20 0.44
CYP2C19 P33261 1/20 0.44
MBTD1 Q05BQ5 1/20 0.43
TP53BP1 Q12888 1/20 0.43
L3MBTL3 Q96JM7 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL922710 0.82 PRMT6 (0.57) PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E
SCHEMBL6736373 0.81 SMN1; SMN2 (0.58) PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E
SCHEMBL6739716 0.78 ALDH1A1 (0.55) PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E
SCHEMBL10702311 0.76 KDM4E (0.67) ALDH1A1KDM4EGAACYP2D6CYP2C9
SCHEMBL6739596 0.76 ALDH1A1 (0.56) PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E
SCHEMBL10077365 0.76 JAK2 (0.61) PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E
SCHEMBL6734904 0.76 DDB1 (0.59) PRMT6ALDH1A1SMN1; SMN2TDP1DDB1
SCHEMBL3846036 0.76 ALDH1A1 (0.62) PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E
SCHEMBL11339852 0.75 PRMT6 (0.78) PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E
SCHEMBL11192726 0.75 PRMT6 (0.78) PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0288519-A4 1-TERTIARY-ALKYL-SUBSTITUTED NAPHTHYRIDINE- AND QUINOLINE-CARBOXYLIC ACID ANTIBACTERIAL AGENTS 1992-04-15 EP disclosed
US-4965273-A Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents BRISTOL-MYERS COMPANY (US) 1990-10-23 US disclosed
US-4954507-A 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents BRISTOL-MYERS COMPANY (US) 1990-09-04 US disclosed
EP-0288519-A1 1-TERTIARY-ALKYL-SUBSTITUTED NAPHTHYRIDINE- AND QUINOLINE-CARBOXYLIC ACID ANTIBACTERIAL AGENTS Bristol-Myers Squibb Company (US) 1988-11-02 EP disclosed
WO-1988002627-A1 1-TERTIARY-ALKYL-SUBSTITUTED NAPHTHYRIDINE- AND QUINOLINE-CARBOXYLIC ACID ANTIBACTERIAL AGENTS BRISTOL-MYERS COMPANY (US) 1988-04-21 WO disclosed