Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 16/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13039503 | 0.81 | HPGD (0.57) | HPGDMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL25855470 | 0.81 | HPGD (0.73) | HPGDMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL44794 | 0.78 | HPGD (0.64) | HPGDMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL25855484 | 0.77 | HPGD (0.63) | HPGDMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL28470037 | 0.77 | HPGD (0.68) | HPGDMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL29039490 | 0.77 | HPGD (0.63) | HPGDMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL22652051 | 0.76 | ALDH1A1 (0.62) | HPGDMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL9693408 | 0.76 | MAPT (0.65) | HPGDMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL3536564 | 0.75 | MAPT (0.97) | HPGDMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL22094933 | 0.75 | MAPT (0.97) | HPGDMAPTALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489547-A1 | A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof | ZENECA LIMITED (GB) | 1992-06-10 | — | — | EP | disclosed |