Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.64 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | PPOX | P50336 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684171 | 0.83 | BACE1 (0.48) | AKR1B1AKR1A1 | |
| SCHEMBL8804611 | 0.78 | AKR1B1 (1.00) | AKR1B1AKR1A1PTGDR2 | |
| SCHEMBL10401578 | 0.70 | AKR1B1 (0.62) | AKR1B1AKR1A1CYP11B2CYP11B1PPOX | |
| SCHEMBL9383374 | 0.69 | AKR1B1 (0.81) | AKR1B1PTGDR2 | |
| SCHEMBL9685858 | 0.68 | AKR1B1 (0.49) | AKR1B1AKR1A1POLBCYP11B2CYP11B1 | |
| SCHEMBL1500415 | 0.67 | ALDH1A1 (0.55) | AKR1B1PPOX | |
| SCHEMBL30661395 | 0.66 | AKR1B1 (0.47) | AKR1B1AKR1A1CYP11B2CYP11B1 | |
| SCHEMBL31186409 | 0.66 | AKR1B1 (0.47) | AKR1B1CYP11B2CYP11B1PTGDR2 | |
| SCHEMBL31212812 | 0.66 | AKR1B1 (0.47) | AKR1B1AKR1A1POLBCYP11B2CYP11B1 | |
| SCHEMBL9918982 | 0.66 | SRD5A1 (0.50) | AKR1B1CYP11B2CYP11B1CMA1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130425-A | Antidiabetic agents spiro azetidine-2,4'(1'H)-isoquinoline! 1',3',4(2'H)-triones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-07-14 | — | — | US | claimed |
| US-5130425-A | Antidiabetic agents spiro azetidine-2,4'(1'H)-isoquinoline! 1',3',4(2'H)-triones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-07-14 | — | — | US | disclosed |