Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | CPT2 | P23786 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781887 | 0.84 | TDP1 (0.48) | TDP1FFAR1CPT2ALDH1A1 | |
| SCHEMBL1782648 | 0.83 | — | — | |
| SCHEMBL1784679 | 0.82 | FFAR1 (0.52) | TDP1FFAR1CPT2 | |
| SCHEMBL8897269 | 0.80 | FFAR1 (0.56) | TDP1FFAR1CPT2 | |
| SCHEMBL19653730 | 0.80 | TDP1 (0.46) | TDP1FFAR1CPT2ALDH1A1SMN1; SMN2 | |
| SCHEMBL1782224 | 0.79 | ALDH1A1 (0.41) | TDP1FFAR1CPT2ALDH1A1 | |
| SCHEMBL1784497 | 0.78 | TDP1 (0.41) | TDP1FFAR1CPT2ALDH1A1 | |
| SCHEMBL1781497 | 0.77 | PAOX (0.43) | TDP1FFAR1CPT2ALDH1A1 | |
| SCHEMBL10264473 | 0.76 | TDP1 (0.83) | TDP1FFAR1CPT2ALDH1A1 | |
| SCHEMBL14924216 | 0.76 | FFAR1 (0.83) | TDP1FFAR1CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270494-B1 | Certain cycloalka- [b]-pyrazolo-[3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY AG (CH) | 1992-08-19 | — | — | EP | disclosed |
| US-4826854-A | Certain cycloalka-(b)-pyrazolo(3,4-d)-pyridin-3-one derivatives | CIBA-GEIGY CORPORATION (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0270494-A2 | Certain cycloalka- [b]-pyrazolo-[3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY AG (CH) | 1988-06-08 | — | — | EP | disclosed |