Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 7/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8984077 | 0.88 | KMT2A (0.67) | KMT2AKDM4EMEN1HTTACHE | |
| SCHEMBL9873305 | 0.81 | ACHE (0.69) | KMT2AKDM4EMEN1HTTACHE | |
| SCHEMBL9875927 | 0.81 | ACHE (0.69) | KMT2AKDM4EMEN1HTTACHE | |
| SCHEMBL9875418 | 0.81 | KDM4E (0.52) | KMT2AKDM4EMEN1HTTACHE | |
| SCHEMBL9875822 | 0.81 | KMT2A (0.57) | KMT2AKDM4EMEN1HTTACHE | |
| SCHEMBL9875000 | 0.81 | KDM4E (0.57) | KMT2AKDM4EMEN1HTTACHE | |
| SCHEMBL9873820 | 0.81 | KDM4E (0.57) | KMT2AKDM4EMEN1HTTACHE | |
| SCHEMBL10847235 | 0.80 | ACHE (0.69) | KMT2AKDM4EMEN1HTTACHE | |
| SCHEMBL10845414 | 0.80 | ACHE (0.58) | KMT2AKDM4EMEN1HTTACHE | |
| SCHEMBL9876065 | 0.79 | KMT2A (0.55) | KMT2AKDM4EMEN1HTTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4753950-A | MEMORY ENHANCEMENT, ALZHEIMER*S DISEASE | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-06-28 | — | — | US | claimed |
| EP-0273176-B1 | FUSED HETEROCYCLIC TETRAHYDROAMINOQUINOLINOLS AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-06-24 | — | — | EP | disclosed |
| EP-0273176-A2 | Fused heterocyclic tetrahydroaminoquinolinols and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-07-06 | — | — | EP | disclosed |
| US-4753950-A | MEMORY ENHANCEMENT, ALZHEIMER*S DISEASE | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-06-28 | — | — | US | disclosed |