Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686555 | 0.86 | GPR119 (0.60) | GPR119PDE3BPDE3APDE2A | |
| SCHEMBL7328135 | 0.86 | PDE3B (0.55) | GPR119PDE3BPDE3APDE2A | |
| SCHEMBL9686024 | 0.83 | PDE3B (0.78) | GPR119PDE3BPDE3A | |
| SCHEMBL2580702 | 0.82 | GPR119 (0.56) | GPR119PDE3BPDE3APDE2A | |
| SCHEMBL9686762 | 0.81 | GPR119 (0.66) | GPR119PDE3BPDE3APDE2A | |
| SCHEMBL6934765 | 0.81 | GPR119 (0.61) | GPR119PDE3BPDE3APDE2A | |
| SCHEMBL9687194 | 0.80 | PDE3B (0.54) | GPR119PDE3BPDE3A | |
| SCHEMBL10333497 | 0.79 | PDE3B (0.55) | GPR119PDE3BPDE3APDE2A | |
| SCHEMBL9781549 | 0.78 | GPR119 (0.55) | GPR119PDE3BPDE3APDE2A | |
| SCHEMBL7340003 | 0.77 | GPR119 (0.53) | GPR119PDE3BPDE3APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |