Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299065 | 0.86 | PDE3B (0.55) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL9686166 | 0.86 | GPR119 (0.55) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL9686024 | 0.83 | PDE3B (0.78) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL9687501 | 0.81 | GPR119 (0.52) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL9686622 | 0.80 | GPR119 (0.56) | PDE3BPDE3AGPR119 | |
| SCHEMBL9687226 | 0.77 | GPR119 (0.49) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL9687496 | 0.77 | GPR119 (0.53) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL7335403 | 0.77 | GPR119 (0.56) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL7298045 | 0.76 | GPR119 (0.63) | PDE3BPDE3AGPR119PDE4B | |
| SCHEMBL7296587 | 0.75 | GPR119 (0.57) | PDE3BPDE3AGPR119PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |