Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 2/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.54 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | GALR3 | O60755 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323542 | 0.87 | PDE3B (0.60) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL9687144 | 0.85 | PDE3B (0.54) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL9686825 | 0.84 | GPR119 (0.46) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL10353457 | 0.83 | PDE3B (0.71) | PDE3BPDE3AMAPTPDE4APDE4B | |
| SCHEMBL4414285 | 0.82 | PDE3B (0.64) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL10369572 | 0.81 | HRH3 (0.59) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL8342501 | 0.80 | PDE3B (0.64) | PDE3BPDE3AMAPTPDE4APDE4B | |
| SCHEMBL10016799 | 0.80 | PDE3B (0.64) | PDE3BPDE3AMAPTPDE4APDE4B | |
| SCHEMBL16156976 | 0.80 | PDE3B (0.57) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL16157196 | 0.80 | PDE3B (0.57) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |