Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1173871 | 0.76 | ATM (0.42) | ATMALOX15POLBALDH1A1LMNA | |
| SCHEMBL1868349 | 0.74 | ATM (0.41) | ATMALOX15POLBALDH1A1LMNA | |
| SCHEMBL9686765 | 0.73 | ATM (0.40) | ATMALOX15POLBALDH1A1LMNA | |
| SCHEMBL69496 | 0.72 | ALDH1A1 (0.46) | ATMALOX15POLBALDH1A1LMNA | |
| SCHEMBL18134201 | 0.72 | ALDH1A1 (0.46) | ATMALOX15POLBALDH1A1LMNA | |
| SCHEMBL383982 | 0.70 | ATM (0.38) | ATMALOX15POLBALDH1A1LMNA | |
| SCHEMBL11242645 | 0.69 | ATM (0.40) | ATMPOLBALDH1A1LMNAHSD17B10 | |
| SCHEMBL8397241 | 0.69 | ATM (0.37) | ATMPOLBALDH1A1LMNAHSD17B10 | |
| SCHEMBL30343256 | 0.69 | ATM (0.37) | ATMPOLBALDH1A1LMNAHSD17B10 | |
| SCHEMBL13992169 | 0.69 | ALDH1A1 (0.42) | ATMALOX15POLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159040-B1 | PYRIDINE DERIVATIVES AND PRODUCTION THEREOF | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1992-12-09 | — | — | EP | disclosed |
| US-5036059-A | Hypotensive agents, vasodilators | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1991-07-30 | — | — | US | disclosed |
| EP-0159040-A2 | Pyridine derivatives and production thereof | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1985-10-23 | — | — | EP | disclosed |