Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | BID | P55957 | 3/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.36 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.36 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4247247 | 0.95 | TLR8 (0.42) | TLR8TSHRBIDMCL1BCL2L1 | |
| SCHEMBL21883584 | 0.93 | BID (0.44) | TLR8TSHRBIDMCL1BCL2L1 | |
| SCHEMBL6457244 | 0.89 | AR (0.39) | TLR8ALDH1A1HPGDL3MBTL1TSHR | |
| SCHEMBL1726412 | 0.82 | TSHR (0.45) | TLR8ALDH1A1HPGDNPC1CASP3 | |
| SCHEMBL7863918 | 0.82 | GABRA1 (0.40) | ALDH1A1TSHRMAPTHTT | |
| SCHEMBL3676124 | 0.81 | TLR8 (0.46) | TLR8BIDMCL1BCL2L1BAK1 | |
| SCHEMBL8861003 | 0.81 | NPC1 (0.40) | ALDH1A1HPGDNPC1CASP3RAB9A | |
| SCHEMBL27740369 | 0.79 | NPC1 (0.40) | ALDH1A1HPGDNPC1CASP3RAB9A | |
| SCHEMBL21884011 | 0.79 | ALOX5 (0.49) | ALDH1A1HPGDNPC1CASP3RAB9A | |
| SCHEMBL84271 | 0.79 | PLAU (0.35) | ALDH1A1SMN1; SMN2TSHRMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101175747-B | Substituted N-arylpyrrolidines as selective androgen receptor modulators | LILLY CO ELI | 2011-06-22 | — | — | CN | disclosed |
| CN-101175747-A | Substituted N-arylpyrrolidines as selective androgen receptor modulators | LILLY CO ELI (US) | 2008-05-07 | — | — | CN | disclosed |
| EP-0245053-B1 | HETEROCYCLIC FUSED TRICYCLIC COMPOUNDS | ICI AMERICAS INC. (US) | 1992-11-25 | — | — | EP | disclosed |
| US-5118688-A | TETRAHYDROPYRIDOQUINOLONE DERIVATIVES USEFUL AS ANXIOLYTIC AGENTS | ICI AMERICAS INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4975435-A | Certain 1H-pyrrold[3,4-b]quinolin-1-one-9-amino-2,3-dihydro derivatives useful for treating anxiety | ICI AMERICAS INC. (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0245053-A1 | Heterocyclic fused tricyclic compounds | ICI AMERICAS INC. (US) | 1987-11-11 | — | — | EP | disclosed |
| US-3987192-A | ANTIALLERGENS AND ANTIANAPHYLAXID; 2'-CYANO-OXANILIC ACID | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | disclosed |