Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 3/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3452908 | 0.91 | LMNA (0.80) | LMNAKMT2AMEN1CYP1A2PDE3B | |
| SCHEMBL1392640 | 0.82 | LMNA (0.67) | LMNAKMT2AMEN1CYP1A2PDE3B | |
| SCHEMBL2152989 | 0.82 | LMNA (0.67) | LMNAKMT2AMEN1CYP1A2PDE3B | |
| SCHEMBL4122238 | 0.82 | LMNA (0.67) | LMNAKMT2AMEN1CYP1A2PDE3B | |
| SCHEMBL11035831 | 0.82 | LMNA (1.00) | LMNAKMT2AMEN1CYP1A2PDE3B | |
| SCHEMBL928205 | 0.82 | LMNA (0.67) | LMNAKMT2AMEN1CYP1A2PDE3B | |
| SCHEMBL928226 | 0.82 | LMNA (0.67) | LMNAKMT2AMEN1CYP1A2PDE3B | |
| SCHEMBL481916 | 0.82 | LMNA (0.67) | LMNAKMT2AMEN1CYP1A2PDE3B | |
| SCHEMBL482059 | 0.81 | CYP1A2 (1.00) | LMNAKMT2AMEN1CYP1A2PDE3B | |
| Hydrochloric Acid SCHEMBL7316011 | 0.80 | LMNA (0.65) | LMNAKMT2AMEN1CYP1A2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |