SCHEMBL482059

SCHEMBL482059

O=c1ccc(-c2ccccc2)n[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 1.00
LMNA P02545 3/20 0.66
KMT2A Q03164 2/20 0.66
MEN1 O00255 1/20 0.66
GPR119 Q8TDV5 1/20 0.55
PDE3B Q13370 3/20 0.54
PDE3A Q14432 3/20 0.54
MAPT P10636 1/20 0.51
POLB P06746 1/20 0.50
RAB9A P51151 1/20 0.50
PDE4A P27815 1/20 0.50
PDE4B Q07343 1/20 0.50
PDE4C Q08493 1/20 0.50
PDE4D Q08499 1/20 0.50
TP53 P04637 1/20 0.48
L3MBTL1 Q9Y468 3/20 0.48
AKR1B1 P15121 2/20 0.47
HPGD P15428 2/20 0.47
KDM4E B2RXH2 1/20 0.47
BTK Q06187 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7689907 0.98 CYP1A2 (0.96) CYP1A2LMNAKMT2AMEN1GPR119
SCHEMBL3452908 0.89 LMNA (0.80) CYP1A2LMNAKMT2AMEN1GPR119
SCHEMBL8898883 0.85 CYP1A2 (0.73) CYP1A2LMNAKMT2AMEN1GPR119
SCHEMBL10353459 0.85 CYP1A2 (0.74) CYP1A2LMNAKMT2AMEN1GPR119
SCHEMBL11146636 0.84 CYP1A2 (0.71) CYP1A2LMNAKMT2AMEN1GPR119
SCHEMBL1456606 0.81 CYP1A2 (0.67) CYP1A2LMNAKMT2AMEN1GPR119
SCHEMBL9687063 0.81 LMNA (0.69) CYP1A2LMNAKMT2AMEN1GPR119
SCHEMBL1751891 0.81 CYP1A2 (0.68) CYP1A2LMNAKMT2AMEN1PDE3B
SCHEMBL11156334 0.80 CYP1A2 (0.67) CYP1A2LMNAKMT2AMEN1PDE3B
SCHEMBL10354174 0.80 CYP1A2 (0.67) CYP1A2LMNAKMT2AMEN1GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 328 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110984423-B Construction method of reinforced concrete wall 广东高翔建设有限公司 2021-03-30 CN claimed
CN-110984423-A Construction method of reinforced concrete wall 广东高翔建设有限公司 2020-04-10 CN claimed
CN-110606716-A Construction method of indoor partition wall 广东优鼎装饰设计工程有限公司 2019-12-24 CN claimed
CN-106831600-B The preparation method of 3- phenyl -4-6- dichloro-pyridazine 常州沃腾化工科技有限公司 2019-04-12 CN claimed
CN-106831600-A The preparation method of the dichloro-pyridazine of 3 phenyl 46 常州沃腾化工科技有限公司 2017-06-13 CN claimed
US-8747643-B2 Plating bath and method ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2014-06-10 US claimed
US-20140027298-A1 PLATING BATH AND METHOD ROHM & HAAS ELECT MAT (US) 2014-01-30 US claimed
US-20130048505-A1 PLATING BATH AND METHOD ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2013-02-28 US claimed
US-4397854-A INCREASE IN MYOCARDIAL CONTRACTILITY WARNER-LAMBERT COMPANY (US) 1983-08-09 US claimed
JP-55036434-A None JP disclosed
JP-55118470-A None JP disclosed
JP-55139364-A None JP disclosed
JP-55139363-A None JP disclosed
WO-2025215121-A1 HEDGEHOG ACYLTRANSFERASE INHIBITORS IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) 2025-10-16 WO disclosed
JP-S55139364-A PYRIDAZONE DERIVATIVE, AND AGRICULTURAL AND HORTICULTURAL GERMICIDE CONTAINING SAID DERIVATIVE AS EFFECTIVE COMPONENT SANKYO CO LTD 1980-10-31 JP disclosed
JP-S55118470-A THIOUREA DERIVATIVE MORISHITA SEIYAKU KK 1980-09-11 JP disclosed
JP-S5536434-A 4-PHENYL-4-OXO-2-BUTENOIC ACID DERIVATIVE AND ITS PREPARATION SANKYO CO LTD 1980-03-14 JP disclosed
EP-0002719-A2 Process for the preparation of 3-pyridazinones HOECHST AKTIENGESELLSCHAFT (DE) 1979-07-11 EP disclosed
US-4152517-A CYCLIZATION WITH HYDRAZINE SMITHKLINE CORPORATION (US) 1979-05-01 US disclosed
US-4008086-A PYRIDONE OR PYRIDAZONE DERIVATIVES KONISHIROKU PHOTO INDUSTRY CO., LTD. (JA) 1977-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130048505-A1 PLATING BATH AND METHOD EPHX1, CYP7B1, AOC3 CYP1A2 48/4885LMNA 1720/4885KMT2A 1456/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.