Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686444 | 0.90 | DPP4 (0.54) | DPP4PDE10AGSK3BCHRM2DRD1 | |
| SCHEMBL9687439 | 0.89 | DPP4 (0.54) | DPP4PDE10ARPS6KB1CHRM2DRD1 | |
| SCHEMBL9686860 | 0.87 | KDM4E (0.44) | DPP4CHRM2DRD1 | |
| SCHEMBL9685621 | 0.85 | DPP4 (0.55) | DPP4GSK3BCHRM2DRD1 | |
| SCHEMBL9686958 | 0.84 | LMNA (0.41) | DPP4CHRM2DRD1 | |
| SCHEMBL9686438 | 0.79 | DPP4 (0.68) | DPP4GSK3BCHRM2DRD1 | |
| SCHEMBL9687780 | 0.79 | DPP4 (0.40) | DPP4CHRM2DRD1 | |
| Hydrochloric Acid SCHEMBL9687485 | 0.78 | DPP4 (0.40) | DPP4CHRM2DRD1 | |
| SCHEMBL9636153 | 0.78 | ALDH1A1 (0.53) | CHRM2 | |
| SCHEMBL10873725 | 0.78 | DPP4 (0.40) | DPP4CHRM2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187376-A2 | 6,7-Disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids | BAYER AG (DE) | 1986-07-16 | — | — | EP | claimed |
| EP-0187376-B1 | 6,7-DISUBSTITUTED 1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| EP-0187376-A2 | 6,7-Disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids | BAYER AG (DE) | 1986-07-16 | — | — | EP | disclosed |