Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.53 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.51 |
| ▸ | HTR1A known ✓ | P08908 | 3/20 | 0.50 |
| ▸ | HTR1D known ✓ | P28221 | 2/20 | 0.50 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.50 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9361263 | 0.98 | CHRM3 (0.54) | CHRM3BLMALDH1A1LMNAPMP22 | |
| Bromide SCHEMBL9688708 | 0.87 | DRD2 (0.61) | HTR1AHTR7DRD2DRD3 | |
| SCHEMBL7776686 | 0.85 | DRD2 (0.63) | HTR1AHTR7DRD2DRD3 | |
| SCHEMBL8970384 | 0.76 | CHRM2 (0.60) | CHRM3CHRM2CHRM1HTR1ADRD2 | |
| SCHEMBL266906 | 0.76 | DRD2 (0.74) | CHRM3ALDH1A1CHRM2CHRM1HTR1A | |
| Hydrochloric Acid SCHEMBL9688982 | 0.75 | CHRM2 (0.59) | CHRM3CHRM2CHRM1HTR1ADRD2 | |
| SCHEMBL4813078 | 0.74 | CHRM3 (0.65) | CHRM3BLMALDH1A1LMNAPMP22 | |
| SCHEMBL11471209 | 0.74 | CHRM3 (0.49) | CHRM3BLMALDH1A1LMNAPMP22 | |
| SCHEMBL1689733 | 0.73 | PLAU (0.55) | HTR1AHTR2AHTR2C | |
| SCHEMBL11824955 | 0.73 | CHRM3 (0.58) | CHRM3BLMALDH1A1LMNAPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130339-A | Intestine and uterine motility modulators for reduction of intraocular pressure for glaucoma treatment | SANOFI (FR) | 1992-07-14 | — | — | US | disclosed |