Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.60 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9688982 | 0.98 | CHRM2 (0.59) | CHRM2CHRM1CHRM3HTR1ASIGMAR1 | |
| SCHEMBL9365199 | 0.89 | DRD2 (0.66) | CHRM2CHRM1CHRM3SIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL9688990 | 0.88 | DRD2 (0.64) | CHRM2CHRM1CHRM3SIGMAR1DRD2 | |
| SCHEMBL8132467 | 0.84 | CHRM2 (0.60) | CHRM2CHRM1CHRM3HTR1ASIGMAR1 | |
| SCHEMBL25286780 | 0.82 | ADRA1A (0.62) | CHRM2CHRM1CHRM3HTR1ADRD2 | |
| SCHEMBL30510683 | 0.82 | ADRA1A (0.62) | CHRM2CHRM1CHRM3HTR1ADRD2 | |
| SCHEMBL8124399 | 0.82 | HTR1A (0.46) | CHRM2CHRM1CHRM3HTR1ASIGMAR1 | |
| SCHEMBL12671717 | 0.81 | CHRM2 (0.67) | CHRM2CHRM1CHRM3HTR1ASIGMAR1 | |
| SCHEMBL338362 | 0.80 | DRD2 (0.55) | CHRM2CHRM1CHRM3HTR1ASIGMAR1 | |
| SCHEMBL19835985 | 0.80 | MTNR1A (0.56) | CHRM2CHRM1CHRM3HTR1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585392-A | TREATING OR PREVENTING STROKES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| US-5506246-A | Method for treating depression using substituted aminomethyltetralins and their heterocyclic analogues | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-09 | — | — | US | disclosed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| EP-0436435-B1 | Phenylethanolaminomethyltetralins, procedure for their preparation and pharmaceutical compositions containing same | SANOFI ELF (FR) | 1994-03-23 | — | — | EP | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0436435-A1 | Phenylethanolaminomethyltetralins, procedure for their preparation and pharmaceutical compositions containing same | ELF SANOFI (FR) | 1991-07-10 | — | — | EP | disclosed |
| EP-0352613-A2 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1990-01-31 | — | — | EP | disclosed |