Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.42 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.47 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HLA-A | P04439 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9687648 | 1.00 | KCNH2 (0.47) | KCNH2SSTR5HRH1HRH4NR4A2 | |
| Oxalic Acid SCHEMBL9630287 | 0.84 | SSTR5 (0.49) | KCNH2SSTR5HRH1HRH4NR4A2 | |
| Oxalic Acid SCHEMBL9630277 | 0.84 | SSTR5 (0.49) | KCNH2SSTR5HRH1HRH4NR4A2 | |
| SCHEMBL9870928 | 0.84 | MEN1 (0.38) | KCNH2SSTR5CYP2D6HTTMEN1 | |
| Oxalic Acid SCHEMBL9690858 | 0.82 | SSTR5 (0.46) | KCNH2SSTR5HRH1HRH4NR4A2 | |
| Oxalic Acid SCHEMBL9690852 | 0.82 | SSTR5 (0.46) | KCNH2SSTR5HRH1HRH4NR4A2 | |
| SCHEMBL9630514 | 0.82 | SSTR5 (0.48) | KCNH2SSTR5HRH1HRH4NR4A2 | |
| SCHEMBL9687682 | 0.80 | SSTR5 (0.52) | KCNH2SSTR5HRH1HRH4NR4A2 | |
| SCHEMBL9687522 | 0.80 | KCNH2 (0.47) | KCNH2SSTR5HRH1HRH4NR4A2 | |
| Oxalic Acid SCHEMBL9630530 | 0.80 | SSTR5 (0.44) | KCNH2SSTR5HRH1HRH4NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295742-B1 | NOVEL N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-26 | — | — | EP | disclosed |
| US-5006527-A | Antihistamines, antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-09 | — | — | US | disclosed |
| US-4897401-A | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases | JANSSEN PHARMACEUTICAL N.V. (BE) | 1990-01-30 | — | — | US | disclosed |
| EP-0295742-A1 | Novel N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-21 | — | — | EP | disclosed |