Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 13/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 13/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 13/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 13/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 13/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.53 |
| ▸ | GABRA6 | Q16445 | 9/20 | 0.53 |
| ▸ | GABRA4 | P48169 | 8/20 | 0.53 |
| ▸ | GABRP | O00591 | 5/20 | 0.53 |
| ▸ | GABRD | O14764 | 5/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.53 |
| ▸ | GABRE | P78334 | 5/20 | 0.53 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.53 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.53 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688147 | 0.88 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9688204 | 0.84 | GABRA1 (0.50) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9688494 | 0.83 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9687518 | 0.81 | KDM4E (0.44) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL11090801 | 0.81 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9536120 | 0.81 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9536385 | 0.79 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL1981698 | 0.78 | GABRA1 (0.63) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9534774 | 0.75 | GABRA1 (0.53) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL3058011 | 0.73 | KMT2A (0.46) | KMT2AKDM4EPOLBMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237467-B1 | HETEROARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | claimed |