Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.41 |
| ▸ | GABRP | O00591 | 7/20 | 0.41 |
| ▸ | GABRD | O14764 | 7/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.41 |
| ▸ | GABRE | P78334 | 7/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688147 | 0.85 | GABRA1 (0.60) | KDM4EMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL9689016 | 0.85 | FPR2 (0.41) | KDM4EALDH1A1HSD17B10GABRA1GABRG2 | |
| SCHEMBL9689425 | 0.84 | HSPB1 (0.46) | KDM4EMEN1KMT2AALDH1A1POLB | |
| SCHEMBL9687760 | 0.81 | GABRA1 (0.53) | KDM4EMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL9536896 | 0.79 | GABRA1 (0.46) | KDM4EMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL9687542 | 0.78 | GABRA1 (0.64) | KDM4EMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL9018039 | 0.77 | KDM4E (0.44) | KDM4EMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL7502529 | 0.74 | GABRA1 (0.49) | KDM4EMEN1KMT2AALDH1A1GABRA1 | |
| SCHEMBL9534278 | 0.72 | GABRA1 (0.54) | KDM4EMEN1KMT2AALDH1A1GABRA1 | |
| SCHEMBL9536124 | 0.71 | GABRA1 (0.46) | KDM4EKMT2AALDH1A1HSD17B10GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237467-B1 | HETEROARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | claimed |
| EP-0237467-B1 | HETEROARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | disclosed |