Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.32 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1162910 | 0.69 | — | — | |
| SCHEMBL9013546 | 0.69 | — | — | |
| SCHEMBL2127063 | 0.67 | NOS3 (0.57) | ORAI1ORAI2ORAI3 | |
| SCHEMBL1273374 | 0.67 | TSHR (0.36) | — | |
| SCHEMBL2879492 | 0.65 | TSHR (0.35) | ORAI1ORAI2ORAI3 | |
| SCHEMBL34907 | 0.63 | — | — | |
| SCHEMBL17100617 | 0.63 | — | — | |
| SCHEMBL27177616 | 0.57 | CES1 (0.37) | — | |
| SCHEMBL2885325 | 0.57 | TSHR (0.50) | — | |
| SCHEMBL338538 | 0.56 | CES1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |