Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689490 | 0.91 | HRH3 (0.50) | DRD2HRH3 | |
| SCHEMBL10365748 | 0.87 | HRH3 (0.47) | DRD2HRH3 | |
| SCHEMBL10365750 | 0.86 | HRH3 (0.48) | DRD2HRH3 | |
| SCHEMBL9036589 | 0.83 | SIGMAR1 (0.51) | DRD2HTR2AHTR1ALMNAMAPT | |
| SCHEMBL9688155 | 0.82 | PARP1 (0.47) | DRD2HTR2AHTR1AHTR7DRD3 | |
| SCHEMBL9689437 | 0.82 | PARP1 (0.47) | DRD2HTR2AHTR1AHTR7DRD3 | |
| SCHEMBL9689528 | 0.82 | PARP1 (0.47) | DRD2HTR2AHTR1AHTR7DRD3 | |
| SCHEMBL9640183 | 0.82 | SIRT6 (0.47) | DRD2HTR2AHTR1AHTR7DRD3 | |
| Hydrochloric Acid SCHEMBL9690356 | 0.81 | PARP1 (0.46) | DRD2HTR2AHTR1AHTR7DRD3 | |
| Hydrochloric Acid SCHEMBL9690279 | 0.81 | PARP1 (0.46) | DRD2HTR2AHTR1AHTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| US-5120843-A | Nervous system disorders | UPJOHN (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | disclosed |
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |