Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | HTR6 | P50406 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR1F | P30939 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9816424 | 0.88 | FOLH1 (0.66) | MAPTCYP3A4HTR6HTR1ADRD2 | |
| SCHEMBL9501275 | 0.84 | HTR6 (0.57) | MAPTCYP3A4HTR6HTR1ADRD2 | |
| SCHEMBL21808612 | 0.81 | KDM4E (0.51) | MAPTHTR6FOLH1KDM4EALDH1A1 | |
| SCHEMBL29756470 | 0.81 | KDM4E (0.51) | MAPTHTR6FOLH1KDM4EALDH1A1 | |
| SCHEMBL6215070 | 0.78 | KDM4E (0.47) | MAPTCYP3A4HTR6FOLH1KDM4E | |
| SCHEMBL6141995 | 0.77 | GAA (0.50) | MAPTCYP3A4HTR6HTR1ADRD2 | |
| 2-Methyl Gramine SCHEMBL2519973 | 0.76 | MAPT (1.00) | MAPTCYP3A4HTR6KDM4EALDH1A1 | |
| SCHEMBL6947949 | 0.75 | MTNR1A (0.64) | MAPTCYP3A4FOLH1KDM4EALDH1A1 | |
| SCHEMBL4905844 | 0.74 | SCN9A (0.56) | MAPTHTR6HTR1ADRD2DRD4 | |
| SCHEMBL4906035 | 0.74 | KDM4E (0.51) | MAPTHTR6FOLH1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5159080-A | Treatment of heart-circulation disorders | MADAUS AG (DE) | 1992-10-27 | — | — | US | disclosed |