Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913941 | 0.82 | PDE10A (0.61) | PDE10ANCF1CYP1A2CYSLTR2CYSLTR1 | |
| SCHEMBL14352218 | 0.81 | PDE10A (0.46) | PDE10AALDH1A1CYP1A2CYSLTR2CYSLTR1 | |
| SCHEMBL2924050 | 0.81 | NCF1 (0.53) | PDE10ANCF1LMNACYP1A2CYSLTR2 | |
| SCHEMBL30331437 | 0.81 | NCF1 (0.46) | PDE10ANCF1LMNACYP1A2CYSLTR2 | |
| SCHEMBL24197398 | 0.81 | NCF1 (0.46) | PDE10ANCF1LMNACYP1A2CYSLTR2 | |
| SCHEMBL22493232 | 0.81 | PDE10A (0.47) | PDE10ANCF1CYP1A2CYSLTR2CYSLTR1 | |
| SCHEMBL29858122 | 0.80 | HTT (0.55) | ALDH1A1CYP1A2 | |
| SCHEMBL19385987 | 0.80 | HTT (0.55) | ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL7830119 | 0.79 | NCF1 (0.52) | PDE10ANCF1LMNACYP1A2CYSLTR2 | |
| SCHEMBL725176 | 0.79 | PDE10A (0.54) | PDE10AALDH1A1CYP1A2CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |