Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 6/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688588 | 0.99 | MAPT (0.46) | MAPTTP53MTNR1AMTNR1BCYP2C9 | |
| SCHEMBL9688594 | 0.86 | TP53 (0.45) | MAPTTP53MTNR1AMTNR1BDNM1 | |
| SCHEMBL10472794 | 0.86 | TP53 (0.40) | MAPTTP53MTNR1AMTNR1BLMNA | |
| Hydrochloric Acid SCHEMBL9688836 | 0.84 | TP53 (0.43) | MAPTTP53MTNR1AMTNR1BDNM1 | |
| SCHEMBL9688715 | 0.84 | HRH3 (0.43) | MAPTTP53MEN1KMT2A | |
| Water SCHEMBL9688643 | 0.83 | HRH3 (0.42) | MAPTTP53MEN1KMT2A | |
| SCHEMBL9688077 | 0.83 | HPGD (0.46) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL9687687 | 0.80 | HDAC1 (0.42) | MAPTTP53MEN1KMT2ARXFP1 | |
| SCHEMBL9687505 | 0.78 | ACHE (0.44) | MAPTTP53KMT2AHDAC3HDAC1 | |
| SCHEMBL9687734 | 0.76 | NAMPT (0.45) | MAPTTP53LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | claimed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | claimed |
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | disclosed |
| US-4968699-A | CENTRAL NERVOUS SYSTEM; ANTIISCHEMIC AND ANTIHYPOXIC AGENTS; ACTIVE AGAINST CEREBRAL OXYGEN DEFICIENCY | BEECHAM-WUELFING GMBH & CO. (DE) | 1990-11-06 | — | — | US | disclosed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | disclosed |