Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 8/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9688643 | 0.99 | HRH3 (0.42) | HRH3HTR7GAAMEN1KMT2A | |
| SCHEMBL9688674 | 0.86 | HRH3 (0.47) | HRH3HTR7GAAMAPTGLS | |
| SCHEMBL10472794 | 0.86 | TP53 (0.40) | MEN1KMT2AMAPTTP53 | |
| SCHEMBL9688588 | 0.84 | MAPT (0.46) | MEN1KMT2AMAPTTP53 | |
| Hydrochloric Acid SCHEMBL9689421 | 0.84 | HRH3 (0.48) | HRH3HTR7GAAGLS | |
| SCHEMBL9688077 | 0.83 | HPGD (0.46) | GAAMEN1KMT2AMAPTTP53 | |
| SCHEMBL9797249 | 0.75 | TP53 (0.42) | MEN1KMT2ATP53 | |
| SCHEMBL9687687 | 0.74 | HDAC1 (0.42) | MEN1KMT2AMAPTTP53 | |
| SCHEMBL10378913 | 0.73 | TP53 (0.38) | MEN1KMT2AMAPTCYP3A4NPSR1 | |
| SCHEMBL9687505 | 0.72 | ACHE (0.44) | KMT2AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | claimed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | claimed |