Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.46 |
| ▸ | ICMT | O60725 | 9/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9687340 | 0.88 | HTR2A (0.48) | HTR6ICMTHTR1AHTR1DHTR1B | |
| SCHEMBL19123468 | 0.77 | HTR1A (0.45) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL4123642 | 0.71 | HTR6 (0.46) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL9687324 | 0.70 | HTR1A (0.57) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL9688555 | 0.70 | HTR6 (0.57) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| Hydrochloric Acid SCHEMBL9687692 | 0.70 | HTR1A (0.56) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL13651695 | 0.70 | HTR1A (0.56) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL14051801 | 0.68 | HTR1A (0.61) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| Succinic Acid SCHEMBL5962591 | 0.68 | HTR6 (0.49) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL10464895 | 0.68 | HTR6 (0.59) | HTR6HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500086-A1 | Indole derivatives, their use as medicines and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1992-08-26 | — | — | EP | disclosed |