Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687548 | 0.89 | NPC1 (0.48) | RAB9ANPC1GAAHDAC1HDAC6 | |
| SCHEMBL9687497 | 0.89 | NAMPT (0.43) | GAAHDAC1HDAC6KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL10377827 | 0.88 | NPC1 (0.48) | RAB9ANPC1GAAMEN1KMT2A | |
| SCHEMBL9688606 | 0.87 | NPC1 (0.44) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL9688571 | 0.87 | NPC1 (0.52) | RAB9ANPC1GAAMEN1KMT2A | |
| SCHEMBL9689157 | 0.86 | NPC1 (0.51) | RAB9ANPC1GAAMEN1KMT2A | |
| SCHEMBL9687727 | 0.86 | NAMPT (0.46) | RAB9ANPC1GAAHDAC1MEN1 | |
| SCHEMBL9687884 | 0.85 | ALDH1A1 (0.53) | RAB9ANPC1GAAMEN1KMT2A | |
| SCHEMBL10377571 | 0.85 | NPC1 (0.43) | RAB9ANPC1GAAMEN1KMT2A | |
| SCHEMBL10377756 | 0.85 | NPC1 (0.48) | RAB9ANPC1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | claimed |
| EP-0167901-B1 | ACTIVE COMPOUNDS | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-04-04 | — | — | EP | claimed |
| EP-0167901-A2 | Active compounds | LES LABORATOIRES BEECHAM S.A. (FR) | 1986-01-15 | — | — | EP | claimed |
| EP-0167901-B1 | ACTIVE COMPOUNDS | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-04-04 | — | — | EP | disclosed |
| US-4853391-A | Pyrido[1,2-a]indoles and their use as cardiovascular | LABORATOIRES SOBIO SA, 13-15-25 BOULEVARD DE 1'AMIRAL BRUIX 75782 PARIS, CEDEX 16, FRANCE | 1989-08-01 | — | — | US | disclosed |