Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688855 | 0.85 | RAB9A (0.47) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9687548 | 0.85 | NPC1 (0.48) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL9688772 | 0.84 | ALDH1A1 (0.54) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL10377827 | 0.84 | NPC1 (0.48) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL9687727 | 0.83 | NAMPT (0.46) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL9689157 | 0.83 | NPC1 (0.51) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL10377571 | 0.82 | NPC1 (0.43) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL10377756 | 0.82 | NPC1 (0.48) | ALDH1A1MAPTPOLBLMNARAB9A | |
| SCHEMBL9687710 | 0.80 | NPC1 (0.42) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL10377807 | 0.80 | NPC1 (0.42) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | claimed |
| EP-0167901-B1 | ACTIVE COMPOUNDS | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-04-04 | — | — | EP | claimed |
| US-4853391-A | Pyrido[1,2-a]indoles and their use as cardiovascular | LABORATOIRES SOBIO SA, 13-15-25 BOULEVARD DE 1'AMIRAL BRUIX 75782 PARIS, CEDEX 16, FRANCE | 1989-08-01 | — | — | US | claimed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | claimed |
| EP-0167901-A2 | Active compounds | LES LABORATOIRES BEECHAM S.A. (FR) | 1986-01-15 | — | — | EP | claimed |
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | disclosed |
| US-4968699-A | CENTRAL NERVOUS SYSTEM; ANTIISCHEMIC AND ANTIHYPOXIC AGENTS; ACTIVE AGAINST CEREBRAL OXYGEN DEFICIENCY | BEECHAM-WUELFING GMBH & CO. (DE) | 1990-11-06 | — | — | US | disclosed |
| US-4853391-A | Pyrido[1,2-a]indoles and their use as cardiovascular | LABORATOIRES SOBIO SA, 13-15-25 BOULEVARD DE 1'AMIRAL BRUIX 75782 PARIS, CEDEX 16, FRANCE | 1989-08-01 | — | — | US | disclosed |
| US-4837240-A | ANTIISCHEMIC, ANTHIHYPOXIC AGENTS | BEECHAM-WUELFING GMBH & CO. KG (FR) | 1989-06-06 | — | — | US | disclosed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | disclosed |
| EP-0252643-A1 | Pyrido[1,2-a]indole derivatives, process for their preparation and pharmaceutical compounds containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-01-13 | — | — | EP | disclosed |
| EP-0167901-A2 | Active compounds | LES LABORATOIRES BEECHAM S.A. (FR) | 1986-01-15 | — | — | EP | disclosed |