Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539176 | 0.95 | TP53 (0.62) | TP53PDE4BPDE4DHCAR1ALDH1A1 | |
| SCHEMBL16084474 | 0.88 | PDE4B (0.52) | TP53PDE4BPDE4DHCAR1ALDH1A1 | |
| SCHEMBL5775620 | 0.86 | PDE4B (0.54) | TP53PDE4BPDE4DHCAR1ALDH1A1 | |
| SCHEMBL5778683 | 0.86 | PDE4B (0.54) | TP53PDE4BPDE4DHCAR1ALDH1A1 | |
| SCHEMBL5775573 | 0.86 | PDE4B (0.54) | TP53PDE4BPDE4DHCAR1ALDH1A1 | |
| SCHEMBL2790752 | 0.79 | TP53 (0.65) | TP53PDE4BPDE4DPOLBALOX15 | |
| SCHEMBL12893949 | 0.76 | TP53 (0.59) | TP53PDE4BPDE4DPOLBHTR3E | |
| SCHEMBL6160948 | 0.75 | TP53 (0.58) | TP53PDE4BPDE4DALDH1A1HSD17B10 | |
| SCHEMBL9685823 | 0.74 | RPS6KB1 (0.47) | TP53ALDH1A1MEN1MAPTPKM | |
| SCHEMBL13319030 | 0.73 | TP53 (0.62) | TP53PDE4BPDE4DALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |