Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689070 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2HSD17B10MAOBKMT2AMEN1 | |
| SCHEMBL9688839 | 0.83 | SMN1; SMN2 (0.44) | SMN1; SMN2HSD17B10MAOBKMT2AMEN1 | |
| SCHEMBL526662 | 0.82 | SMN1; SMN2 (0.58) | SMN1; SMN2HSD17B10MAOBKMT2AMEN1 | |
| SCHEMBL9688698 | 0.80 | RECQL (0.66) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL9689246 | 0.76 | TSHR (0.44) | SMN1; SMN2HSD17B10KMT2AMEN1ALDH1A1 | |
| SCHEMBL9689136 | 0.76 | NPC1 (0.54) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL9688758 | 0.76 | MAPT (0.46) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9689750 | 0.75 | ALDH1A1 (0.44) | HSD17B10KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL9689705 | 0.75 | MAPT (0.35) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL9689112 | 0.75 | NPC1 (0.40) | SMN1; SMN2HSD17B10MAOBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |