Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689107 | 0.88 | TDP1 (0.41) | NPC1RAB9ASMN1; SMN2CNR2HSD17B10 | |
| SCHEMBL9690007 | 0.85 | RECQL (0.54) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL9687969 | 0.82 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL9689245 | 0.82 | HPGD (0.46) | NPC1RAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL9688171 | 0.81 | PADI1 (0.41) | NPC1RAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL9792307 | 0.81 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2MAPTPKM | |
| SCHEMBL9689339 | 0.80 | MEN1 (0.36) | NPC1RAB9AMAPTCNR2HSD17B10 | |
| SCHEMBL9690049 | 0.80 | ALDH1A1 (0.39) | NPC1RAB9AMAPTALDH1A1KDM4E | |
| SCHEMBL9687966 | 0.79 | TAS1R3 (0.42) | NPC1RAB9AMAPTCNR2ALDH1A1 | |
| SCHEMBL9689149 | 0.79 | LMNA (0.39) | NPC1RAB9ASMN1; SMN2MAPTCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |