Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 12/20 | 0.57 |
| ▸ | DRD4 | P21917 | 12/20 | 0.57 |
| ▸ | DRD3 | P35462 | 12/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 9/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 9/20 | 0.57 |
| ▸ | CHRM5 | P08912 | 9/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 9/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11292859 | 0.90 | HTR2A (0.78) | HTR2APOLBDRD2DRD4DRD3 | |
| SCHEMBL1309037 | 0.87 | HTR2A (0.69) | HTR2APOLBDRD2DRD4DRD3 | |
| SCHEMBL8248673 | 0.87 | HTR2A (0.79) | HTR2APOLBDRD2DRD4DRD3 | |
| SCHEMBL4656369 | 0.84 | HTR7 (0.57) | HTR2ADRD2DRD4DRD3 | |
| SCHEMBL14277003 | 0.83 | POLB (0.61) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL17979351 | 0.83 | DRD2 (0.69) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL30483504 | 0.83 | DRD2 (0.69) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL5385733 | 0.83 | POLB (0.66) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL17969134 | 0.80 | POLB (0.67) | HTR2APOLBDRD2DRD4DRD3 | |
| SCHEMBL5661091 | 0.80 | CHRM2 (0.67) | POLBDRD2DRD4DRD3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |