Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689142 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2HSD17B10CYP1A2CYP2C19CNR2 | |
| SCHEMBL9792251 | 0.81 | CYP1A2 (0.49) | SMN1; SMN2HSD17B10CYP1A2CYP2C19MAPT | |
| SCHEMBL9689290 | 0.80 | SMN1; SMN2 (0.66) | SMN1; SMN2HSD17B10CYP1A2CYP2C19CNR2 | |
| SCHEMBL9689174 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2HSD17B10CYP1A2CYP2C19CNR2 | |
| SCHEMBL9689112 | 0.78 | NPC1 (0.40) | SMN1; SMN2HSD17B10CNR2MAPTRAB9A | |
| SCHEMBL9689264 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2HSD17B10CYP1A2CYP2C19CNR2 | |
| SCHEMBL9690007 | 0.77 | RECQL (0.54) | SMN1; SMN2CYP1A2CYP2C19MAPTRAB9A | |
| SCHEMBL10487745 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2HSD17B10CYP1A2CYP2C19CNR2 | |
| SCHEMBL9690049 | 0.75 | ALDH1A1 (0.39) | MAPTRAB9AKMT2AMEN1KDM4E | |
| SCHEMBL9687969 | 0.74 | NPC1 (0.52) | SMN1; SMN2MAPTRAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |