Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9689682 | 0.99 | NPC1 (0.53) | NPC1RAB9AMITFPKMMAOB | |
| SCHEMBL9690480 | 0.80 | NPC1 (0.46) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL29703262 | 0.79 | NPC1 (0.63) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL9689666 | 0.77 | GAA (0.38) | NPC1RAB9AMITFPKMKMT2A | |
| SCHEMBL10044417 | 0.76 | NPC1 (0.62) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL9027681 | 0.76 | TDP1 (0.72) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL29703247 | 0.76 | TDP1 (0.72) | NPC1RAB9AMITFPKMTDP1 | |
| Hydrochloric Acid SCHEMBL9689680 | 0.76 | SIGMAR1 (0.51) | NPC1RAB9AMITFPKMTDP1 | |
| Hydrochloric Acid SCHEMBL30088832 | 0.75 | TDP1 (0.70) | NPC1RAB9AMITFPKMTDP1 | |
| SCHEMBL6216387 | 0.74 | NPC1 (0.64) | NPC1RAB9AMITFPKMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |