Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PER2 | O15055 | 5/20 | 0.35 |
| ▸ | CRY1 | Q16526 | 5/20 | 0.35 |
| ▸ | CRY2 | Q49AN0 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690278 | 0.81 | NPC1 (0.39) | NPC1MITFPKMRAB9AMEN1 | |
| SCHEMBL9689620 | 0.77 | NPC1 (0.54) | NPC1MITFPKMRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL9689682 | 0.76 | NPC1 (0.53) | NPC1MITFPKMRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL9688314 | 0.67 | GRIN2B (0.39) | HPGDMEN1KMT2ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL9690298 | 0.66 | KCNH2 (0.47) | NPC1MITFPKMRAB9AHPGD | |
| SCHEMBL9689668 | 0.65 | PHGDH (0.41) | MEN1KMT2AKDM4ELMNAMAPK1 | |
| SCHEMBL9690480 | 0.65 | NPC1 (0.46) | GAANPC1MITFPKMRAB9A | |
| SCHEMBL29703262 | 0.64 | NPC1 (0.63) | NPC1MITFPKMRAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL9689762 | 0.64 | NPC1 (0.39) | NPC1MITFPKMRAB9AMEN1 | |
| SCHEMBL4085550 | 0.63 | NPC1 (0.46) | GAANPC1MITFPKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |