Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689503 | 0.84 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL17148037 | 0.80 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL9689635 | 0.78 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL9688757 | 0.77 | CYSLTR1 (0.61) | SMN1; SMN2MAPK1KMT2AHPGDMEN1 | |
| 2-(Phenoxymethyl)Benzothiazole SCHEMBL2245843 | 0.76 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL4638323 | 0.75 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL10832358 | 0.75 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL8139922 | 0.73 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL9689338 | 0.72 | LOXL2 (0.42) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL9689601 | 0.72 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291916-B1 | DITHIOACETAL COMPOUNDS, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-08-12 | — | — | EP | disclosed |
| US-5081126-A | QUINOLYL- AND ISOQUINOLYL-METHOXYPHENYL-DITHIOACETYL DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-01-14 | — | — | US | disclosed |
| US-4963576-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS; 5-LIPOXYGENASE INHIBITOR | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1990-10-16 | — | — | US | disclosed |
| EP-0291916-A1 | Dithioacetal compounds, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-11-23 | — | — | EP | disclosed |