Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689163 | 0.86 | RECQL (0.43) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9688754 | 0.86 | RECQL (0.43) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9689339 | 0.77 | MEN1 (0.36) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9688864 | 0.77 | TSHR (0.44) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9687989 | 0.76 | ELANE (0.38) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9690069 | 0.75 | MEN1 (0.34) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9688839 | 0.74 | SMN1; SMN2 (0.44) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9690056 | 0.73 | RAB9A (0.54) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9689826 | 0.73 | MAPT (0.46) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9689317 | 0.73 | LMNA (0.46) | RECQLMEN1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |