Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | PTGES | O14684 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689777 | 0.84 | MEN1 (0.56) | MEN1KMT2AALDH1A1GAAHPGD | |
| SCHEMBL6744201 | 0.84 | KMT2A (0.69) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL12808838 | 0.84 | ALDH1A1 (0.60) | MEN1KMT2AALDH1A1GAAHPGD | |
| SCHEMBL31201812 | 0.83 | ESR1 (0.65) | MEN1KMT2AALDH1A1GAAHPGD | |
| SCHEMBL9464466 | 0.80 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1GAAHPGD | |
| SCHEMBL2558736 | 0.80 | SMN1; SMN2 (0.61) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL10972849 | 0.79 | LMNA (0.59) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL18460328 | 0.78 | ALDH1A1 (0.63) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL18423718 | 0.78 | MEN1 (0.68) | MEN1KMT2AALDH1A1GAAHPGD | |
| SCHEMBL6744892 | 0.78 | KMT2A (0.56) | MEN1KMT2AALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |