Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812100 | 0.88 | RECQL (0.50) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL9792291 | 0.83 | MEN1 (0.35) | ALDH1A1MEN1KMT2APOLBPARP1 | |
| SCHEMBL9689213 | 0.82 | KMT2A (0.39) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL9690069 | 0.80 | MEN1 (0.34) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL9688851 | 0.80 | NPSR1 (0.48) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL9689799 | 0.80 | MAPT (0.36) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL9689156 | 0.78 | NPSR1 (0.32) | LMNA | |
| SCHEMBL9689783 | 0.78 | TSHR (0.36) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL9688824 | 0.78 | TSHR (0.38) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL9688156 | 0.76 | MAPT (0.46) | ALDH1A1MAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |