Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689213 | 0.83 | KMT2A (0.39) | RAB9ALMNASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL8812100 | 0.82 | RECQL (0.50) | TSHRRAB9ALMNACYP1A2CYP2C19 | |
| SCHEMBL9792282 | 0.82 | SMN1; SMN2 (0.36) | TSHRRAB9ALMNACYP1A2CYP2C19 | |
| SCHEMBL11062054 | 0.80 | SMN1; SMN2 (0.34) | TSHRRAB9ALMNACYP1A2CYP2C19 | |
| SCHEMBL9688824 | 0.80 | TSHR (0.38) | TSHRRAB9ALMNACYP1A2CYP2C19 | |
| SCHEMBL9734727 | 0.79 | CASP3 (0.31) | — | |
| SCHEMBL9689958 | 0.78 | ALDH1A1 (0.37) | LMNAALDH1A1MEN1KMT2ARECQL | |
| SCHEMBL9688851 | 0.78 | NPSR1 (0.48) | RAB9ALMNANPC1CYP2C9ALDH1A1 | |
| SCHEMBL9689996 | 0.78 | GLA (0.33) | TSHRCYP1A2CYP2C19CYP3A4NPSR1 | |
| SCHEMBL9690069 | 0.78 | MEN1 (0.34) | TSHRLMNACYP1A2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |