Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812100 | 0.86 | RECQL (0.50) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL9688824 | 0.83 | TSHR (0.38) | KMT2ASMN1; SMN2HSD17B10PTGS1PTGS2 | |
| SCHEMBL9689783 | 0.83 | TSHR (0.36) | KMT2ASMN1; SMN2NPC1RAB9AGLA | |
| SCHEMBL9792224 | 0.83 | SMN1; SMN2 (0.38) | KMT2ASMN1; SMN2HSD17B10PTGS1PTGS2 | |
| SCHEMBL9688851 | 0.82 | NPSR1 (0.48) | KMT2ANPC1RAB9AGLANPSR1 | |
| SCHEMBL9690069 | 0.82 | MEN1 (0.34) | KMT2AHSD17B10GLANPSR1MEN1 | |
| SCHEMBL9689996 | 0.82 | GLA (0.33) | GLANPSR1 | |
| SCHEMBL9689958 | 0.82 | ALDH1A1 (0.37) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9689799 | 0.81 | MAPT (0.36) | KMT2ANPC1RAB9AGLANPSR1 | |
| SCHEMBL9688875 | 0.80 | SMN1; SMN2 (0.54) | KMT2ASMN1; SMN2HSD17B10RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |