SCHEMBL9689968

SCHEMBL9689968

C#Cc1cccc(C=O)c1C#C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
LMNA P02545 2/20 0.42
THRB P10828 1/20 0.42
BLM P54132 1/20 0.42
ERN1 O75460 4/20 0.38
ALDH1A1 P00352 3/20 0.35
TRIM24 O15164 2/20 0.35
TRIM33 Q9UPN9 2/20 0.35
TSHR P16473 1/20 0.35
CYP2A6 P11509 1/20 0.33
TLR2 O60603 1/20 0.32
TLR1 Q15399 1/20 0.32
TLR6 Q9Y2C9 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
HPGD P15428 1/20 0.32
HTT P42858 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31574357 0.87 KMT2A (0.50) KMT2AMEN1TDP1LMNATHRB
SCHEMBL711033 0.80 LMNA (0.55) KMT2AMEN1TDP1LMNATHRB
SCHEMBL9699060 0.79 ALDH1A1 (0.46) KMT2AMEN1TDP1LMNATHRB
Benzene SCHEMBL28197607 0.78 LMNA (0.52) KMT2AMEN1TDP1LMNATHRB
SCHEMBL24653160 0.78 ERN1 (0.52) KMT2AMEN1TDP1LMNATHRB
SCHEMBL9842365 0.78 TDP1 (0.41) KMT2AMEN1TDP1LMNATHRB
SCHEMBL16653119 0.78 ERN1 (0.61) KMT2AMEN1TDP1LMNATHRB
SCHEMBL20798207 0.78 ERN1 (0.42) KMT2AMEN1TDP1LMNATHRB
SCHEMBL32666059 0.78 ERN1 (0.42) KMT2AMEN1TDP1LMNATHRB
SCHEMBL16653118 0.78 ERN1 (0.55) KMT2AMEN1TDP1LMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0257309-B1 PROCESS FOR THE PREPARATION OF ETHYNYLBENZALDEHYDES National Starch and Chemical Investment Holding Corporation (US) 1992-02-05 EP claimed