Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TTPA | P49638 | 2/20 | 0.40 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 4/20 | 0.37 |
| ▸ | ACHE | P22303 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689587 | 0.86 | CYP4F2 (0.44) | MAPTLMNAMEN1KMT2ATTPA | |
| SCHEMBL9689581 | 0.83 | CYP4F2 (0.45) | MAPTLMNAMEN1KMT2ATTPA | |
| SCHEMBL9690161 | 0.82 | MAPT (0.41) | MAPTLMNAMEN1KMT2ATTPA | |
| SCHEMBL9467677 | 0.80 | CYP4F2 (0.52) | MAPTLMNAMEN1KMT2ATTPA | |
| SCHEMBL9689556 | 0.75 | CYP4F2 (0.43) | MAPTLMNAMEN1KMT2ATTPA | |
| SCHEMBL9690390 | 0.75 | ALOX5 (0.50) | MAPTLMNAMEN1KMT2ATTPA | |
| SCHEMBL17289289 | 0.72 | NR1I2 (0.50) | MAPTLMNAMEN1KMT2ATTPA | |
| SCHEMBL9689071 | 0.72 | ALOX5 (0.48) | MAPTLMNAMEN1KMT2ATTPA | |
| SCHEMBL20764885 | 0.72 | NR1I2 (0.50) | MAPTLMNAMEN1KMT2ATTPA | |
| SCHEMBL2059245 | 0.72 | ACHE (0.56) | BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | claimed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |