Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 18/20 | 0.63 |
| ▸ | BCHE | P06276 | 17/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690224 | 0.97 | ACHE (0.61) | ACHEBCHEPTGS1PTGS2CYP1A2 | |
| SCHEMBL2058864 | 0.93 | PTGS1 (0.60) | ACHEBCHEPTGS1PTGS2CYP1A2 | |
| SCHEMBL2059491 | 0.87 | PTGS1 (0.62) | ACHEBCHEPTGS1PTGS2CYP1A2 | |
| SCHEMBL2058855 | 0.83 | PTGS1 (0.62) | ACHEBCHEPTGS1PTGS2CYP1A2 | |
| SCHEMBL9314334 | 0.82 | PTGS1 (0.61) | ACHEBCHEPTGS1PTGS2CYP1A2 | |
| SCHEMBL2059279 | 0.82 | PTGS1 (0.61) | ACHEBCHEPTGS1PTGS2CYP1A2 | |
| SCHEMBL2059293 | 0.82 | PTGS1 (0.61) | ACHEBCHEPTGS1PTGS2CYP1A2 | |
| SCHEMBL2059199 | 0.82 | PTGS1 (0.61) | ACHEBCHEPTGS1PTGS2CYP1A2 | |
| SCHEMBL2058872 | 0.82 | PTGS1 (0.64) | ACHEBCHEPTGS1PTGS2CYP1A2 | |
| SCHEMBL9689071 | 0.82 | ALOX5 (0.48) | ACHEBCHEPTGS1PTGS2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | claimed |
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | claimed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | claimed |