Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22144684 | 1.00 | ALKBH5 (0.44) | ALKBH5DDB1CRBNHDAC8ALDH1A1 | |
| SCHEMBL19370861 | 0.84 | CRBN (0.60) | DDB1CRBN | |
| SCHEMBL4389196 | 0.84 | CRBN (0.60) | DDB1CRBN | |
| SCHEMBL4396934 | 0.84 | CRBN (0.60) | DDB1CRBN | |
| SCHEMBL1398171 | 0.78 | CRBN (0.45) | ALKBH5DDB1CRBNGAATSHR | |
| Phenol SCHEMBL9521307 | 0.74 | CRBN (0.39) | ALKBH5DDB1CRBNHDAC8ALDH1A1 | |
| SCHEMBL9326554 | 0.74 | DDB1 (0.70) | DDB1CRBNSMN1; SMN2GAATSHR | |
| SCHEMBL3742060 | 0.73 | MAPK1 (0.49) | ALDH1A1SMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL15398330 | 0.73 | VEGFA (0.49) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL3744061 | 0.73 | VEGFA (0.49) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0302372-B1 | NAPHTHYRIDINE ANTIANAEROBIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-12-16 | — | — | EP | disclosed |
| EP-0302372-A1 | Naphthyridine antianaerobic compounds | ABBOTT LABORATORIES (US) | 1989-02-08 | — | — | EP | disclosed |