Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 15/20 | 0.70 |
| ▸ | CRBN | Q96SW2 | 15/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940107 | 0.90 | GAA (0.75) | DDB1CRBNGAATSHR | |
| SCHEMBL21965481 | 0.82 | DDB1 (1.00) | DDB1CRBN | |
| SCHEMBL22144430 | 0.76 | GAA (0.57) | DDB1CRBNGAATSHR | |
| SCHEMBL28865590 | 0.75 | CRBN (0.49) | DDB1CRBNGAATSHRSMN1; SMN2 | |
| SCHEMBL22144684 | 0.74 | ALKBH5 (0.44) | DDB1CRBNGAATSHRSMN1; SMN2 | |
| SCHEMBL9690902 | 0.74 | ALKBH5 (0.44) | DDB1CRBNGAATSHRSMN1; SMN2 | |
| SCHEMBL21965358 | 0.74 | DDB1 (0.82) | DDB1CRBN | |
| SCHEMBL22119641 | 0.73 | TSHR (0.50) | DDB1CRBNGAATSHRNFKB1 | |
| SCHEMBL9366340 | 0.73 | CRBN (0.73) | DDB1CRBNGAANFKB1NFKB2 | |
| SCHEMBL26328760 | 0.73 | DDB1 (0.71) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257433-B1 | Method for the preparation of quinoline-2,3-dicarboxylic acid | AMERICAN CYANAMID CO (US) | 1994-03-23 | — | — | EP | claimed |
| EP-0257433-A2 | Method for the preparation of quinoline-2,3-dicarboxylic acid | AMERICAN CYANAMID COMPANY (US) | 1988-03-02 | — | — | EP | claimed |
| WO-2020132561-A1 | TARGETED PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| EP-0257433-B1 | Method for the preparation of quinoline-2,3-dicarboxylic acid | AMERICAN CYANAMID CO (US) | 1994-03-23 | — | — | EP | disclosed |
| US-4757146-A | Method for the preparation of quinoline-2,3-dicarboxylic acid | AMERICAN CYANAMID COMPANY (US) | 1988-07-12 | — | — | US | disclosed |
| EP-0257433-A2 | Method for the preparation of quinoline-2,3-dicarboxylic acid | AMERICAN CYANAMID COMPANY (US) | 1988-03-02 | — | — | EP | disclosed |