SCHEMBL969119

SCHEMBL969119

CCOC(=O)Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1C

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.59
MAPT P10636 2/20 0.59
KMT2A Q03164 2/20 0.59
KDM4E B2RXH2 1/20 0.59
HSP90AA1 P07900 1/20 0.59
CRHBP P24387 1/20 0.59
CRHR2 Q13324 1/20 0.59
PPARD Q03181 8/20 0.49
PPARA Q07869 6/20 0.49
PPARG P37231 4/20 0.49
NPC1 O15118 2/20 0.49
ALDH1A1 P00352 1/20 0.49
GAA P10253 1/20 0.49
TRPM8 Q7Z2W7 1/20 0.47
POLB P06746 1/20 0.46
PKM P14618 1/20 0.44
NFKB1 P19838 1/20 0.44
RAB9A P51151 1/20 0.44
NFKB2 Q00653 1/20 0.44
RELA Q04206 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4906319 0.89 MAPT (0.49) MEN1MAPTKMT2AKDM4EHSP90AA1
SCHEMBL4473367 0.88 MAPT (0.57) MEN1MAPTKMT2AKDM4EHSP90AA1
SCHEMBL6604649 0.86 TRPM8 (0.56) MEN1MAPTKMT2APPARAPPARG
SCHEMBL4899851 0.86 LMNA (0.47) MEN1MAPTKMT2AKDM4EHSP90AA1
SCHEMBL4905523 0.84 MAPT (0.56) MEN1MAPTKMT2AKDM4ENPC1
SCHEMBL14573031 0.83 PPARD (0.63) MEN1MAPTKMT2AKDM4EHSP90AA1
SCHEMBL3534461 0.83 TRPM8 (0.47) MEN1MAPTKMT2AKDM4EHSP90AA1
SCHEMBL27689187 0.81 MAPT (0.53) MEN1MAPTKMT2AKDM4EHSP90AA1
SCHEMBL18015833 0.80 MAPT (0.50) MEN1MAPTKMT2AKDM4EHSP90AA1
SCHEMBL20642209 0.80 MAPT (0.68) MEN1MAPTKMT2AKDM4EHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7872032-B2 1, 3, 4-oxadiazol-2-ones as PPAR delta modulators and their use thereof AVENTIS PARMACEUTICALS INC. (US) 2011-01-18 US disclosed
US-7872032-B2 1, 3, 4-oxadiazol-2-ones as PPAR delta modulators and their use thereof AVENTIS PARMACEUTICALS INC. (US) 2011-01-18 US disclosed
US-7872032-B2 1, 3, 4-oxadiazol-2-ones as PPAR delta modulators and their use thereof AVENTIS PARMACEUTICALS INC. (US) 2011-01-18 US disclosed
US-7638539-B2 1, 3, 4-oxadiazol-2-ones as peroxisome-proliferator activated receptor delta modulators and their use in the treatment of neurological and metabolic disease AVENTIS PHARMACEUTICALS INC. (US) 2009-12-29 US disclosed
US-7638539-B2 1, 3, 4-oxadiazol-2-ones as peroxisome-proliferator activated receptor delta modulators and their use in the treatment of neurological and metabolic disease AVENTIS PHARMACEUTICALS INC. (US) 2009-12-29 US disclosed
US-7638539-B2 1, 3, 4-oxadiazol-2-ones as peroxisome-proliferator activated receptor delta modulators and their use in the treatment of neurological and metabolic disease AVENTIS PHARMACEUTICALS INC. (US) 2009-12-29 US disclosed
US-20090275621-A1 1, 3, 4-OXADIAZOL-2-ONES AS PPAR DELTA MODULATORS AND THEIR USE THEREOF AVENTIS PHARMACEUTICALS INC. (US) 2009-11-05 US disclosed
US-20090275621-A1 1, 3, 4-OXADIAZOL-2-ONES AS PPAR DELTA MODULATORS AND THEIR USE THEREOF AVENTIS PHARMACEUTICALS INC. (US) 2009-11-05 US disclosed
US-20090275621-A1 1, 3, 4-OXADIAZOL-2-ONES AS PPAR DELTA MODULATORS AND THEIR USE THEREOF AVENTIS PHARMACEUTICALS INC. (US) 2009-11-05 US disclosed
CN-101287718-A Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER PROD INC (US) 2008-10-15 CN disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 US disclosed
EP-1781648-A2 1,3,4-OXADIAZOL-2-ONES AS PPAR DELTA MODULATORS Aventis Pharmaceuticals Inc. (US) 2007-05-09 EP disclosed
US-20070099964-A1 1, 3, 4-OXADIAZOL-2-ONES AS PEROXISOME-PROLIFERATOR ACTIVATED RECEPTOR DELTA MODULATORS AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL AND METABOLIC DISEASE AVENTIS PHARMACEUTICALS INC. (US) 2007-05-03 US disclosed
US-20070099964-A1 1, 3, 4-OXADIAZOL-2-ONES AS PEROXISOME-PROLIFERATOR ACTIVATED RECEPTOR DELTA MODULATORS AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL AND METABOLIC DISEASE AVENTIS PHARMACEUTICALS INC. (US) 2007-05-03 US disclosed
US-20070099964-A1 1, 3, 4-OXADIAZOL-2-ONES AS PEROXISOME-PROLIFERATOR ACTIVATED RECEPTOR DELTA MODULATORS AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL AND METABOLIC DISEASE AVENTIS PHARMACEUTICALS INC. (US) 2007-05-03 US disclosed
EP-1765796-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS Pfizer Products Inc. (US) 2007-03-28 EP disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 US disclosed
WO-2006003495-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER PRODUCTS INC. (US) 2006-01-12 WO disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 US disclosed
WO-2005097763-A2 1,3,4-OXADIAZOL-2-ONES AS PPAR DELTA AVENTIS PHARMACEUTICALS INC. (US) 2005-10-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD MEN1 4859/4885MAPT 1858/4885KMT2A 3602/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD MEN1 4855/4885MAPT 1786/4885KMT2A 3530/4885
US-20090275621-A1 1, 3, 4-OXADIAZOL-2-ONES AS PPAR DELTA MODULATORS AND THEIR USE THEREOF PPARD, PPARA, PPARG MEN1 4789/4885MAPT 487/4885KMT2A 4308/4885
US-20070099964-A1 1, 3, 4-OXADIAZOL-2-ONES AS PEROXISOME-PROLIFERATOR ACTIVATED RECEPTOR DELTA MODULATORS AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL AND METABOLIC DISEASE PPARD, PPARA, PPARG MEN1 4508/4885MAPT 338/4885KMT2A 3738/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD MEN1 4855/4885MAPT 1786/4885KMT2A 3530/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.