Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 3/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11168071 | 0.92 | KDM4E (0.43) | CACNA1CCACNA1FCACNA1DCACNA1SKDM4E | |
| SCHEMBL9689489 | 0.91 | KDM4E (0.53) | CACNA1CCACNA1FCACNA1DCACNA1SKDM4E | |
| SCHEMBL9691237 | 0.88 | KDM4E (0.48) | CACNA1CCACNA1FCACNA1DCACNA1SKDM4E | |
| SCHEMBL9839106 | 0.88 | ALDH1A1 (0.47) | KDM4EALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL9691795 | 0.87 | KDM4E (0.45) | CACNA1CCACNA1FCACNA1DCACNA1SKDM4E | |
| SCHEMBL9691628 | 0.87 | KDM4E (0.47) | CACNA1CCACNA1FCACNA1DCACNA1SKDM4E | |
| SCHEMBL9691784 | 0.87 | ALDH1A1 (0.48) | KDM4EALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL9690779 | 0.86 | KDM4E (0.46) | CACNA1CCACNA1FCACNA1DCACNA1SKDM4E | |
| SCHEMBL9691230 | 0.86 | KDM4E (0.46) | CACNA1CCACNA1FCACNA1DCACNA1SKDM4E | |
| SCHEMBL9865585 | 0.85 | CYP1A2 (0.58) | CACNA1CCACNA1FCACNA1DCACNA1SKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071819-B2 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1992-06-10 | — | — | EP | disclosed |
| EP-0071819-B1 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1987-04-22 | — | — | EP | disclosed |
| EP-0158138-A1 | 1-Alkyl-substituted 1,4-dihydropyridine lactones, method for their preparation and their use in medicines | BAYER AG (DE) | 1985-10-16 | — | — | EP | disclosed |
| EP-0071819-A1 | Dihydropyridines with a positive inotropic activity, their use in pharmaceutical preparations, and processes for their preparation | BAYER AG (DE) | 1983-02-16 | — | — | EP | disclosed |